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KMID : 0385020000160030201
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Korean Journal of Laboratory Animal Science
2000 Volume.16 No. 3 p.201 ~ p.205
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Effect of Selenium(Se)Deficiency on Methylmercury(MeHg)Distribution in Mice
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Park, Kyu Sang
Lee, Min Jae/Kim, Choong Yong/Kim, Yeon Seung/Yang, Je Hoong/Lee, Byeong Noh/Kim, Yoo Kyum
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Abstract
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Effect of selenium (Se) deficiency on the distribution of methylmercury (MeHg) was investigated in Se-deficient mice. BALB/c male mice were given Se-deficient or Se-replete diets for 3 weeks. They were orally administered for 2 days with methylmercury chloride (10 ㎎/㎏ b.w.) or saline. The Se-deficient mice showed marked decreases in the level of Se and activity of GSH-Px in the liver as expected. The Se-deficiency increased the concentration of MeHg in the kidney, while decreased it in the liver, RBC, and brain. Thus, this finding indicated that the Se deficiency is a modifying factor to alter the distribution of MeHg.
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